The Portuguese side lead 2-1 from the first leg, which they won after a highly-controversial quick free-kick.
Porto have lost all six of their trips to London - including a 1-0 loss at Chelsea in this season's group stage - and went down 4-0 to the Gunners during September 2008.
However, Ferreira believes tomorrow night's encounter, in which Arsenal must do without injured captain Cesc Fabregas, will be different.
Porto have plenty of options in attack - with Colombia forward Falcao, Argentinian Marian Gonzalez, Uruguay's Cristian Rodriguez and Brazil international Hulk all pressing to be included in the three-man frontline.